Inspiring book:

Lifespan. Why we age - and why we don't have to

by David Sinclair, Prof, Harvard Medical School, 2019

Excerpts:

Over the past century we have gained additional years, but not additional life - not life worth living anyway, We are dying slowly and painfully. People in rich countries often spend a decade or more suffering through illness after illness at the end of their lives. We think this is normal.

The United States spends hundreds of billions of dollars each year fighting cardiovascular disease.15 But if we could stop all cardiovascular disease—every single case, all at once—we wouldn’t add many years to the average lifespan; the gain would be just 1.5 years. The same is true for cancer; stopping all forms of that scourge would give us just 2.1 more years of life on average, because all other causes of death still increase exponentially. We’re still aging, after all.

It’s true: there are no biological, chemical, or physical laws that say life must end. Yes, aging is an increase in entropy, a loss of information leading to disorder. But living things are not closed systems. Life can potentially last forever, as long as it can preserve critical biological information and absorb energy from somewhere in the universe. This doesn’t mean we could be immortal tomorrow

—no more than we could have flown to the moon on December 18, 1903. Science moves forward with small steps and big steps, but always one step at a time.

A study of more than 41,000 metformin users between the ages of 68 and 81 concluded that metformin reduced the likelihood of dementia, cardiovascular disease, cancer, frailty, and depression, and not by a small amount.

The beauty of metformin is that it impacts many diseases. Through the power of AMPK activation, it makes more NAD and turns on sirtuins and other defenses against aging as a whole—engaging the survival circuit upstream of these conditions, ostensibly slowing the loss of epigenetic information and keeping metabolism in check, so all organs stay younger and healthier.

Barzilai is leading the charge to make metformin the first drug to be approved to delay the most common age-related diseases by addressing their root cause: aging itself. If Barzilai and his colleagues can show metformin has measurable benefits in the ongoing Targeting Aging with Metformin (TAME) study, the US

Food and Drug Administration has agreed to consider aging as a treatable condition. That would be a game changer, the beginning of the end for a world in which aging is “just the way it goes.”

************

Intermittant fasting, exercises that raises heart and respiration rate and cold therapy activate longevity genes. And Metformin, Resveratrol, NMN...

J’aime

Commenter

Partager

Life is good. Slow down and take a breath of fresh air...: What to do when your PDF file does not print.

Life is good. Slow down and take a breath of fresh air...: What to do when your PDF file does not print.: I recently had this problem on my desktop PC and after countless search for solutions on the internet that did not work for me (image file p...

What to do when your PDF file does not print.

I recently had this problem on my desktop PC and after countless search for solutions on the internet that did not work for me (image file printing and so on) I accidentally discovered a simple solution to my problem. 

Just go to the basic setting of your printer device and choose the specific output size of your paper (in my case A4) instead of the default "match page size".

Et voilà !